Relationship between plasma lipids and mild cognitive impairment in the elderly Chinese: a case-control study

作者：Qian He, Qing Li, Jiangang Zhao, Tianfeng Wu, Lü Ji, Guowei Huang, Fei Ma · 发表于：Lipids in Health and Disease · 年份：2016 · DOI：10.1186/s12944-016-0320-6 · 被引用次数：97 · 研究领域：Dementia and Cognitive Impairment Research、Alzheimer's disease research and treatments、Diabetes, Cardiovascular Risks, and Lipoproteins

BACKGROUND: High lipid levels may constitute a more important risk factor for cognitive health in previous studies. However, the association of plasma lipids with mild cognitive impairment (MCI) among elderly people had not been studied exactly. This study aims to explore the relationship between plasma lipids/lipoproteins and the risk of MCI in elderly Chinese individuals. METHODS: CSI-MCI study was a preliminary case-control study of the association of plasma lipids/lipoproteins with MCI in 112 MCI cases and 115 cognitively normal controls. Plasma total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) levels were measured in fasting blood samples. Multivariable logistic regression was used to evaluate the potential association between MCI and these factors. Statistical models were adjusted for multiple demographic and biological covariates. RESULTS: The subjects with MCI were significantly older, higher percentage of females and less educated than controls (P <0.05). As expected, subjects with MCI had lower MMSE score compared with controls (P <0.05). Multivariate logistic regression analysis showed that higher plasma TC level was associated with the risk of MCI in models adjusting for age, sex and education. However, This association was attenuated after adjusting for BMI, Type 2 diabetes mellitus, heart disease and hypertension. Plasma TG level was negatively associated with the risk of MCI...