Hypoxia promotes glioma-associated macrophage infiltration via periostin and subsequent M2 polarization by upregulating TGF-beta and M-CSFR

作者：Xiaofan Guo, Hao Xue, Qianqian Shao, Jian Wang, Xing Guo, Xi Chen, Jinsen Zhang, Shugang Xu, Tong Li, Ping Zhang, Xiao Gao, Wei Qiu, Qinglin Liu, Gang Li · 发表于：Oncotarget · 年份：2016 · DOI：10.18632/oncotarget.11825 · 被引用次数：166 · 研究领域：Immune cells in cancer、Glioma Diagnosis and Treatment、Extracellular vesicles in disease

// Xiaofan Guo 1, 2 , Hao Xue 1, 2 , Qianqian Shao 3 , Jian Wang 1, 2, 4 , Xing Guo 1, 2 , Xi Chen 3 , Jinsen Zhang 1, 2 , Shugang Xu 5 , Tong Li 1, 2 , Ping Zhang 1, 2 , Xiao Gao 1, 2 , Wei Qiu 1, 2 , Qinglin Liu 1, 2, * , Gang Li 1, 2, * 1 Department of Neurosurgery, Qilu Hospital of Shandong University, Jinan, Shandong Province, P.R. China 2 Brain Science Research Institute, Shandong University, Jinan, Shandong Province, P.R. China 3 Institute of Basic Medical Sciences and Key Laboratory of Cardiovascular Proteomics of Shandong Province, P.R. China 4 Department of Biomedicine, University of Bergen, Bergen, Norway 5 Department of Neurosurgery, Dezhou People’s Hospital, Dezhou, Shandong Province, P.R. China * These authors have contributed equally to this work Correspondence to: Gang Li, email: ligangqiluhospital@163.com Qinglin Liu, email: bodystrong@126.com Keywords: glioma, hypoxia, tumor-associated macrophage, M2 macrophage, acriflavine Received: March 09, 2016      Accepted: August 13, 2016      Published: September 02, 2016 ABSTRACT Tumor-associated macrophages (TAMs) are enriched in gliomas and help create a tumor-immunosuppressive microenvironment. A distinct M2-skewed type of macrophages makes up the majority of glioma TAMs, and these cells exhibit pro-tumor functions. Gliomas contain large hypoxic areas, and the presence of a correlation between the density of M2-polarized TAMs and hypoxic areas suggests that ...