Metal-Free Remote C–H Bond Amidation of 8-Amidoquinolines on the C5 Position under Mild Conditions

作者：Dezhong Ji, Xin He, Yizhu Xu, Ziyue Xu, Ziyue Xu, Yuchen Bian, Weixing Liu, Qihua Zhu, Yungen Xu, Yungen Xu · 发表于：Organic Letters · 年份：2016 · DOI：10.1021/acs.orglett.6b01980 · 被引用次数：70 · 研究领域：Catalytic C–H Functionalization Methods、Synthesis and Catalytic Reactions、Chemical Synthesis and Analysis

An efficient and facile process was developed for the remote C-H bond amidation of 8-aminoquinoline scaffolds on the C5 position which is geometric. The method only made use of PhI(OAc)2 as a mediator and showed good tolerance toward numerous dibenzenesulfonimides and amides, giving the corresponding products in moderate to excellent yield.