Metabolomic analysis reveals altered metabolic pathways in a rat model of gastric carcinogenesis

作者：Jinping Gu, Xiaomin Hu, Wei Shao, Tianhai Ji, Wensheng Yang, Huiqin Zhuo, Zeyu Jin, Huiying Huang, Jiacheng Chen, Caihua Huang, Donghai Lin · 发表于：Oncotarget · 年份：2016 · DOI：10.18632/oncotarget.11049 · 被引用次数：49 · 研究领域：Metabolomics and Mass Spectrometry Studies、Cancer, Hypoxia, and Metabolism、Cancer, Lipids, and Metabolism

// Jinping Gu 1 , Xiaomin Hu 1 , Wei Shao 1, 3 , Tianhai Ji 3 , Wensheng Yang 3 , Huiqin Zhuo 4 , Zeyu Jin 1 , Huiying Huang 5 , Jiacheng Chen 1 , Caihua Huang 2 , Donghai Lin 1 1 High-field NMR Research Center, MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, P.R. China 2 Department of Physical Education, Xiamen University of Technology, Xiamen, P.R. China 3 Department of Pathology, The Affiliated Chenggong Hospital, Xiamen University, Xiamen, P.R. China 4 Department of Gastrointestinal Surgery, The Affiliated Zhongshan Hospital, Xiamen University, Xiamen, P.R. China 5 State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, P.R. China Correspondence to: Caihua Huang, email: huangcaihua@xmut.edu.cn Donghai Lin, email: dhlin@xmu.edu.cn Keywords: gastric carcinogenesis, metabolic network, metabolic pathways, metabolomics, NMR Received: April 03, 2016      Accepted: July 07, 2016      Published: August 04, 2016 ABSTRACT Gastric cancer (GC) is one of the most malignant tumors with a poor prognosis. Alterations in metabolic pathways are inextricably linked to GC progression. However, the underlying molecular mechanisms remain elusive. We performed NMR-based metabolomic analysis of sera derived from a rat model of gast...