Identification of a novel plasmid-mediated colistin-resistance gene, mcr-2, in Escherichia coli, Belgium, June 2016

作者：Basil Britto Xavier, Christine Lammens, Rohit Ruhal, Samir Kumar‐Singh, Patrick Butaye, Herman Goossens, Surbhi Malhotra‐Kumar · 发表于：Eurosurveillance · 年份：2016 · DOI：10.2807/1560-7917.es.2016.21.27.30280 · 被引用次数：794 · 研究领域：Antibiotic Resistance in Bacteria、Drug Transport and Resistance Mechanisms、Tuberculosis Research and Epidemiology

We identified a novel plasmid-mediated colistin-resistance gene in porcine and bovine colistin-resistant Escherichia coli that did not contain mcr-1. The gene, termed mcr-2, a 1,617 bp phosphoethanolamine transferase harboured on an IncX4 plasmid, has 76.7% nucleotide identity to mcr-1. Prevalence of mcr-2 in porcine colistin-resistant E. coli (11/53) in Belgium was higher than that of mcr-1 (7/53). These data call for an immediate introduction of mcr-2 screening in ongoing molecular epidemiological surveillance of colistin-resistant Gram-negative pathogens.