Antibiotic resistance is the quintessential One Health issue

作者：Timothy P. Robinson, Dengpan Bu, Juan J. Carrique-Mas, Eric Maurice Fèvre, Marius Gilbert, Delia Grace, Simon Iain Hay, Jatesada Jiwakanon, Manish Kakkar, Samuel Kariuki, Ramanan Laxminarayan, Juan Lubroth, Ulf Magnusson, Pham Thi Ngoc, Thomas P. Van Boeckel, Mark E. J. Woolhouse · 发表于：Transactions of the Royal Society of Tropical Medicine and Hygiene · 年份：2016 · DOI：10.1093/trstmh/trw048 · 被引用次数：857 · 研究领域：Antibiotic Use and Resistance、Zoonotic diseases and public health、Climate Change and Health Impacts

In May this year, the long-awaited final report from the Review on Antimicrobial Resistance was published. 1 The report estimates that the 700 000 annual deaths currently attributable to infections by drug-resistant pathogens will increase, if unchecked, to 10 million by 2050, running up a bill of US$100 trillion in terms of lost global production between now and then. The reported numbers are somewhat apocalyptic, as they are based on crude projections of current trends and presume the failure of anti-malarial drugs and antiretroviral therapy as well as antibiotics. Nor do they account for the possible entry of new drugs onto the market. There is huge uncertainty associated with the human burden of antimicrobial resistance (AMR) in general and antibiotic resistance in particular (for the purpose of this article the widely used term antimicrobial resistance [AMR] is retained, though the emphasis here is on antibiotic resistance). The precision of the estimates does not really matter much: the point is that the problem is already immense and is growing rapidly. We have been squandering our antibiotic resources for far too long and immediate action is needed on a very large scale if we are to reverse current trends. It is difficult to imagine an issue that epitomises the principles of One Health more than AMR does. The One Health approach, defined as ‘...the collaborative effort of multiple disciplines – working locally, nationally, and globally – to attain optimal health for p...