The dysconnection hypothesis (2016)

作者：Karl Friston, Harriet R. Brown, Jakob Siemerkus, Klaas Ε. Stephan · 发表于：Schizophrenia Research · 年份：2016 · DOI：10.1016/j.schres.2016.07.014 · 被引用次数：616 · 研究领域：Functional Brain Connectivity Studies、Mental Health Research Topics、Genetic Neurodegenerative Diseases

Twenty years have passed since the dysconnection hypothesis was first proposed (Friston and Frith, 1995; Weinberger, 1993). In that time, neuroscience has witnessed tremendous advances: we now live in a world of non-invasive neuroanatomy, computational neuroimaging and the Bayesian brain. The genomics era has come and gone. Connectomics and large-scale neuroinformatics initiatives are emerging everywhere. So where is the dysconnection hypothesis now? This article considers how the notion of schizophrenia as a dysconnection syndrome has developed - and how it has been enriched by recent advances in clinical neuroscience. In particular, we examine the dysconnection hypothesis in the context of (i) theoretical neurobiology and computational psychiatry; (ii) the empirical insights afforded by neuroimaging and associated connectomics - and (iii) how bottom-up (molecular biology and genetics) and top-down (systems biology) perspectives are converging on the mechanisms and nature of dysconnections in schizophrenia.