Blood—Biomaterial Interactions: An Overview

作者：Allan S. Hoffman · 发表于：Advances in chemistry series · 年份：1982 · DOI：10.1021/ba-1982-0199.ch001 · 被引用次数：65 · 研究领域：Coagulation, Bradykinin, Polyphosphates, and Angioedema、Polymer Surface Interaction Studies、Hemophilia Treatment and Research

A wide number and great variety of clinically important cardiovascular implants and devises exist. Some (e.g., catheters) may only contact the blood once, and for a relatively short time; others (e.g., kidney dialyzers and blood oxygenators) may be exposed to blood for hours, while tissue implants (e.g., heart valves and vascular grafts) will hopefully last for years, or the lifetime of the patient. All of these implants and devices contain materials that are recognized by blood as foreign; the result is a process of thrombosis often followed by formation of thromboemboli. This process generally involves a sequence of protein adsorption steps followed by blood cell interactions (especially involving platelets). Three possible routes to the formation of blood thrombi may be delineated: (1) the "intrinsic" blood coagulation system involving a series or "cascade" of enzymatic activation steps presumed to begin with the surface activation of a glycoprotein, Factor XII (Hageman Factor),