Juicebox Provides a Visualization System for Hi-C Contact Maps with Unlimited Zoom

作者：Neva C. Durand, James Robinson, Muhammad S. Shamim, Ido Machol, Jill P. Mesirov, Eric S. Lander, Erez Lieberman Aiden · 发表于：Cell Systems · 年份：2016 · DOI：10.1016/j.cels.2015.07.012 · 被引用次数：2643 · 研究领域：Genomics and Chromatin Dynamics、Genomics and Phylogenetic Studies、Chromosomal and Genetic Variations

Hi-C experiments study how genomes fold in 3D, generating contact maps containing features as small as 20 bp and as large as 200 Mb. Here we introduce Juicebox, a tool for exploring Hi-C and other contact map data. Juicebox allows users to zoom in and out of Hi-C maps interactively, just as a user of Google Earth might zoom in and out of a geographic map. Maps can be compared to one another, or to 1D tracks or 2D feature sets.