Four New Tirucallane Triterpenoids from the Fruits of Melia azedarach and Their Cytotoxic Activities

作者：Fang Zhou, Xinhua Ma, Zhijun Li, Wei Li, Weimin Zheng, Zhibiao Wang, Xian‐Ming Zeng, Kai‐Hui Sun, Yonghong Zhang · 发表于：Chemistry & Biodiversity · 年份：2016 · DOI：10.1002/cbdv.201600149 · 被引用次数：32 · 研究领域：Phytochemical compounds biological activities、Insect Pest Control Strategies、Tannin, Tannase and Anticancer Activities

Four new tirucallane triterpenoids, (21 S ,23 R ,24 R )‐21,23‐epoxy‐21,24‐dihydroxy‐25‐methoxytirucall‐7‐en‐3‐one ( 2 ), (3 S ,21 S ,23 R ,24 S )‐21,23‐epoxy‐21,25‐dimethoxytirucall‐7‐ene‐3,24‐diol ( 8 ), (21 S ,23 R ,24 R )‐21,23‐epoxy‐24‐hydroxy‐21‐methoxytirucalla‐7,25‐dien‐3‐one ( 11 ), and (21 S ,23 R ,24 R )‐21,23‐epoxy‐21,24‐dihydroxytirucalla‐7,25‐dien‐3‐one ( 12 ), along with 16 known analogues, 1 , 3 – 7 , 9 – 10 , and 13 – 20 , were isolated from the fruits of Melia azedarach . Their structures were elucidated by spectroscopic methods including 1D‐ and 2D‐ NMR techniques and mass spectrometry. These compounds were evaluated for their cytotoxicities against HepG2 (liver), SGC 7901 (stomach), K562 (leukemia), and HL 60 (leukemia) cancer cell lines. Compound 20 exhibited potent cytotoxicity against HepG2 and SGC 7901 cancer cells with the IC 50 values of 6.9 and 6.9 μ m , respectively.