Injectable and Cytocompatible Tough Double‐Network Hydrogels through Tandem Supramolecular and Covalent Crosslinking

作者：Christopher B. Rodell, Neville N. Dusaj, Christopher B. Highley, Jason A. Burdick · 发表于：Advanced Materials · 年份：2016 · DOI：10.1002/adma.201602268 · 被引用次数：291 · 研究领域：Hydrogels: synthesis, properties, applications、Advanced Materials and Mechanics、3D Printing in Biomedical Research

Double-network theory is extended to include guest-host interactions, enabling injectability and cytcompatibility of tough hydrogels. Noncovalent interactions are used as a sacrificial network to toughen covalently crosslinked hydrogels formed from hyaluronic acid. Shear thinning of supramolecular bonds allows hydrogel injection and rapid self-healing, while gentle reaction conditions permit cell encapsulation with high viability.