Fundamentals and Applications of Enzymatic Modifications of Proteins: An Overview

作者：John R. Whitaker, ANTOINE J. PUIGSERVER · 发表于：Advances in chemistry series · 年份：1982 · DOI：10.1021/ba-1982-0198.ch002 · 被引用次数：29 · 研究领域：Protein Hydrolysis and Bioactive Peptides、Enzyme Production and Characterization、Enzyme Catalysis and Immobilization

Enzymes catalyze two types of modifications of proteins, that of hydrolytic and of nonhydrolytic modifications. These modifications, occurring in vivo during or after translation of the protein, are highly specific and may affect markedly the biological, chemical, and physical properties of the protein. Specific proteolysis can be a control process, allowing the biological activity of a number of proteins to be expressed. It also is an intracellular control process since proteins are continuously undergoing degradation at rates that are highly specific for each protein. Many highly specific proteases must occur in rather small amounts in vivo in order to account for the multiplicity of physiological roles in which they are involved. This chapter examines primarily some of the hydrolytic reactions that occur in vivo in the hope that some of the knowledge can be adapted to the hydrolytic modification of food proteins.