Succinate Dehydrogenase: An Ideal Target for Fungicide Discovery

作者：Li Xiong, Yan‐Qing Shen, Lina Jiang, Xiao‐Lei Zhu, Wen‐Chao Yang, Wei Huang, Guang‐Fu Yang · 发表于：ACS symposium series · 年份：2015 · DOI：10.1021/bk-2015-1204.ch013 · 被引用次数：89 · 研究领域：Fungal Plant Pathogen Control、Plant Pathogens and Fungal Diseases、Plant Disease Resistance and Genetics

The mitochondrial respiratory complex II or succinate dehydrogenase (SDH), an essential component of cellular respiratory chain and tricarboxylic acid (or Krebs) cycle, is an ideal target for fungicide development. SDH inhibitors (SDHIs) displayed a broad-spectrum activity against various fungal species. Over the last two decades, great achievements have been made in revealing the function and structure of complex II. Currently, 18 SDHIs have been developed as agricultural fungicides. Although SDHIs as agricultural fungicides have been applied for near fifty years, in order to prevent or delay the onset of resistance to SDHIs, we continue to uncover exciting future prospects for novel fungicides targeting SDH. In this review, we have summarized the structures of complex II of different species, the interactions between complex II and inhibitors, the progress of SDHIs discovery and the resistance to SDHI fungicides.