Anti-DNA antibodies react with DNA expressed on the surface of monocytes and B lymphocytes.

作者：Robert M. Bennett, Julianne Davis, M Merritt · 发表于：PubMed · 年份：1986 · 被引用次数：26 · 研究领域：Monoclonal and Polyclonal Antibodies Research、Immunotherapy and Immune Responses、RNA Interference and Gene Delivery

It is becoming increasingly apparent that nuclear antigens can be expressed on the surfaces of certain cells. We provide evidence that anti-DNA antibodies are reactive with DNA on the surface of monocytes and B lymphocytes. The DNA isolated from monocytes sedimented in a 17.8S position, corresponding to a molecular weight of 4.6 X 10(6); it was mainly double-stranded with many short single stranded regions. In one patient with active systemic lupus erythematosus experiments indicated that anti-DNA antibodies had interacted in vivo with the cell surface DNA on monocytes. The functional significance, if any, of these findings remains to be determined.