Hyperbaric oxygen therapy for traumatic brain injury: bench-to-bedside

作者：John-H. Zhang, Qin Hu, Anatol Manaenko, Ting Xu, Zhen‐Ni Guo, Jiping Tang · 发表于：Medical Gas Research · 年份：2016 · DOI：10.4103/2045-9912.184720 · 被引用次数：48 · 研究领域：Traumatic Brain Injury and Neurovascular Disturbances、Diabetic Foot Ulcer Assessment and Management、Spinal Cord Injury Research

Traumatic brain injury (TBI) is a serious public health problem in the United States. Survivors of TBI are often left with significant cognitive, behavioral, and communicative disabilities. So far there is no effective treatment/intervention in the daily clinical practice for TBI patients. The protective effects of hyperbaric oxygen therapy (HBOT) have been proved in stroke; however, its efficiency in TBI remains controversial. In this review, we will summarize the results of HBOT in experimental and clinical TBI, elaborate the mechanisms, and bring out our current understanding and opinions for future studies.