Eukaryotic translation initiation factor 3B accelerates the progression of esophageal squamous cell carcinoma by activating β-catenin signaling pathway

作者：Fengkai Xu, Cheng-Zhi Xu, Jie Gu, Jie Gu, Ronghua Liu, Ronghua Liu, Enyu Huang, Yunfeng Yuan, Guangyin Zhao, Jiahao Jiang, Chen Xu, Chunlai Lu, Yiwei Chu, Chunlai Lu, Di Ge · 发表于：Oncotarget · 年份：2016 · DOI：10.18632/oncotarget.9726 · 被引用次数：33 · 研究领域：RNA and protein synthesis mechanisms、Polyamine Metabolism and Applications、PI3K/AKT/mTOR signaling in cancer

// Fengkai Xu 1, * , Cheng-Zhi Xu 2, * , Jie Gu 1, * , Xiaoming Liu 3 , Ronghua Liu 3 , Enyu Huang 3 , Yunfeng Yuan 1 , Guangyin Zhao 1 , Jiahao Jiang 1 , Chen Xu 4 , Yiwei Chu 3 , Chunlai Lu 1 , Di Ge 1 1 Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, P. R. China 2 Department of Otolaryngology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China 3 Department of Immunology and Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences, Fudan University, Shanghai, P. R. China 4 Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, P. R. China * These authors contributed equally to this work Correspondence to: Di Ge, email: gedi6902@hotmail.com Chunlai Lu, email: lu.chunlai@zs-hospital.sh.cn Yiwei Chu, email: yiwei_chu@126.com Keywords: esophageal squamous cell carcinoma, eukaryotic translation initiation factors 3B, β-catenin signaling pathway Received: October 22, 2015      Accepted: April 28, 2016      Published: May 30, 2016 ABSTRACT Introduction: Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive malignant tumors. Eukaryotic translation initiation factors 3B (EIF3B) is considered to influence tumor proliferation, invasion, apoptosis and cell cycle, which act together to promote the progression of tumors. However, the role of EIF3B in ESCC is unknown. This st...