Non-Invasive Papillary Carcinoma of the Bladder Associated with Carcinoma in Situ

作者：Alex F. Althausen, George R. Prout, James J. Daly · 发表于：The Journal of Urology · 年份：1976 · DOI：10.1016/s0022-5347(17)58916-8 · 被引用次数：449 · 研究领域：Bladder and Urothelial Cancer Treatments、Urinary and Genital Oncology Studies、Urological Disorders and Treatments

We evaluated 129 patients with low grade, low stage transitional cell carcinoma of the bladder with a minimum followup of 5 years. In addition to the phenomena recognized as indicators of a serious clinical problem (grade greater than I, rapid recurrence, multiple tumors and lamina propria invasion) the identification of carcinoma in situ and/or atypia in normal, incidentally resected mucosa adjacent to the tumor was found to be a positive predictor for subsequent muscle invasion. Ten of 12 patients with carcinoma in situ and 9 of 25 patients with atypia were among 39 who experienced invasion.