[Expression and significance of PTEN in nasopharyngeal carcinoma].

作者：Xijin Xu, Haiwei Yang, Xia Huo · 发表于：PubMed · 年份：2004 · 被引用次数：17 · 研究领域：PI3K/AKT/mTOR signaling in cancer、Flavonoids in Medical Research、Cancer Mechanisms and Therapy

OBJECTIVE: To investigate the expression of tumor suppressor gene PTEN in nasopharyngeal carcinomas and the relationship between PTEN and the progression of nasopharyngeal cancer. METHOD: The SABC immunohistochemistry method was employed to detect the expression of PTEN in paraffin-embedded nasopharyngeal carcinoma tissues. The relationship between the geneexpression and clinicopathological features was analyzed. RESULT: Loss of PTEN expression in normal cases (13.3%) was lower than that in nasopharyngeal carcinoma cases (47.8%). Of nasopharyngeal cancer cases, loss of PTEN expression in squama cell nasopharyngeal (58.1%) was higher than that in others tissue type (30.8%); loss of PTEN expression in squama cell nasopharyngeal had correlation with pathological stage, which increased gradually from poorly differentiated to well differentiated squama cell nasopharyngeal; loss of PTEN expression of clinical III-IV stage (78.1%) was higher than that of clinical I-II stage (21.6%). CONCLUSION: It is presumed that PTEN gene deletion may be involved in carcinogenesis and progression of nasopharyngeal carcinoma, and relates to the tissue type, the pathological grade and clinical stage.