Regioselective 2,2,2-Trifluoroethylation of Imidazopyridines by Visible Light Photoredox Catalysis

作者：Mei Zhu, Xin Han, Weijun Fu, Zhiqiang Wang, Bao‐Ming Ji, Xin‐Qi Hao, Mao‐Ping Song, Xu Chen · 发表于：The Journal of Organic Chemistry · 年份：2016 · DOI：10.1021/acs.joc.6b00950 · 被引用次数：97 · 研究领域：Fluorine in Organic Chemistry、Radical Photochemical Reactions、Catalytic C–H Functionalization Methods

A visible-light-induced C-3 selective trifluoroethylation of imidazoheterocycles using 1,1,1-trifluoro-2-iodoethane as trifluoroethyl radical sources was developed. The methodology enables the introduction of a trifluoroethyl group in a fast and efficient reaction under mild conditions with excellent regioselectivities and high functional group tolerance.