Effect of phenobarbital on the disposition of intravenous theophylline

作者：Kenneth M. Piafsky, DANIEL S. SITAR, RICHARD IAN OGILVIE · 发表于：Clinical Pharmacology & Therapeutics · 年份：1977 · DOI：10.1002/cpt1977223336 · 被引用次数：50 · 研究领域：Pharmacological Effects and Toxicity Studies、Epilepsy research and treatment、Pharmaceutical studies and practices

The disposition of intravenous doses of theophylline was determined in normal male subjects before and after treatment with phenobarbital 2 wk. Although there was some variation in disposition of the 2 drugs, there were no significant effects of phenobarbital on theophylline kinetics. We conclude that theophylline dosage need not be altered during concomitant administration of phenobarbital.