Rifampin activity against Staphylococcus epidermidis biofilms.

作者：Gregory Obst, Gagnon Rf, J Prentis, Richards Gk · 发表于：PubMed · 年份：1989 · 被引用次数：9 · 研究领域：Antibiotic Use and Resistance、Clostridium difficile and Clostridium perfringens research、Biosimilars and Bioanalytical Methods

Rifampin has demonstrated remarkable antimicrobial activity against Staphylococcus epidermidis biofilms. Four other antibiotics had no effect when used alone; three of these (clindamycin, gentamicin, and tetracycline) were antagonistic to rifampin when used in combination. Vancomycin was synergistic with rifampin, producing complete killing. Fresh peritoneal dialysis (PD) solution accentuated the antimicrobial activity, whereas spent PD fluid neutralized it.