Copper-Mediated Aerobic Oxidative Synthesis of 3-Bromo-imidazo[1,2- a ]pyridines with Pyridines and Enamides

作者：Xiaoqiang Zhou, Hao Yan, Chaowei Ma, Yongqin He, Ya‐Min Li, Jinhui Cao, Rulong Yan, Guosheng Huang · 发表于：The Journal of Organic Chemistry · 年份：2015 · DOI：10.1021/acs.joc.5b02384 · 被引用次数：38 · 研究领域：Catalytic C–H Functionalization Methods、Phenothiazines and Benzothiazines Synthesis and Activities、Alkaloids: synthesis and pharmacology

A conversion of pyridines and enamides for the synthesis of 3-bromo-imidazo[1,2-a]pyridines was developed by copper-mediated aerobic oxidative coupling in a one-pot manner. This procedure tolerates various functional groups and affords a series of 3-bromo-imidazo[1,2-a]pyridines under mild conditions.