[Effects of artemisinin on proliferation, apoptosis and Caspase-3 expression of rat mesangial cell].

作者：Xili Wu, Wanggang Zhang, Xingmin Shi, Peng An, Wan-sen Sun, Cheng-lin Qiao, Zhu Wang · 发表于：PubMed · 年份：2010 · 被引用次数：2 · 研究领域：Cancer, Stress, Anesthesia, and Immune Response、Historical Medical Research and Treatments、Pharmacological Effects of Natural Compounds

OBJECTIVE: To study the effects of artemisinin on proliferation, apoptosis and Caspase-3 active of rat mesangial cell. METHODS: Rat mesangial cells were incubated with different concentrations of artemisinin, the proliferation, apoptosis and Caspase-3 active of rat mesangial cell were measured by MTT assay, fluorescent inverted microscope and enzyme-labeled analytical instruments respectively. RESULTS: Compared with control group, the proliferation and Caspase-3 expression of mesangial cell of three other groups were significantly different (P < 0.01). Compared with dexamethasone group, there were significant difference effects of proliferation and Caspase-3 expression of mesangial cell in other two groups of identical concentration drugs (P < 0. 01), especially in the artemisinin + glucocorticoid (ArtGC) group, and the effects of three different drugs on the mesangial cell Caspase-3 expression, proliferation and apoptosis had the tendency of depend on dosage, and mass mortality of mesangial cell in the mediate-dosage and high-dosage ArtGC group. CONCLUSION: Artemisinin could inhibit the proliferation of mesangial cell, enhance the expression of Caspase-3 and promote the apoptosis in a dose-dependent manner.