Folate-targeted star-shaped cationic copolymer co-delivering docetaxel and MMP-9 siRNA for nasopharyngeal carcinoma therapy

作者：Tao Liu, Xidong Wu, Yigang Wang, Tao Zhang, Ting Wu, Fang Liu, Wansong Wang, Gang Jiang, Minqiang Xie · 发表于：Oncotarget · 年份：2016 · DOI：10.18632/oncotarget.9771 · 被引用次数：21 · 研究领域：RNA Interference and Gene Delivery、Advanced biosensing and bioanalysis techniques、Dendrimers and Hyperbranched Polymers

// Tao Liu 1 , Xidong Wu 2 , Yigang Wang 3 , Tao Zhang 1 , Ting Wu 4 , Fang Liu 1 , Wansong Wang 5 , Gang Jiang 1 , Minqiang Xie 1 1 Department of Otolaryngology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China 2 Department of Pharmacology, Jiangxi Institute of Materia Medica, Nanchang, 330029, China 3 School of Life Sciences, Zhejiang Sci-Tech University, Hangzhou, 310018, China 4 Department of Light Chemical Engineering, Guangdong Polytechnic, Foshan, 528041, China 5 Medical College of Nanchang University, Nanchang, 330038, China Correspondence to: Tao Liu, email: taoliu18@126.com Minqiang Xie, email: min_qiang_x@hotmail.com Keywords: target, star-shaped, co-delivery Received: March 18, 2016      Accepted: May 16, 2016      Published: June 01, 2016 ABSTRACT The co-delivery of drug and gene has become the primary strategy in cancer therapy. Based on our previous work, to co-deliver docetaxel (DOC) and MMP-9 siRNA more efficiently for HNE-1 nasopharyngeal carcinoma therapy, a folate-modified star-shaped copolymer (FA-CD-PLLD) consisting of β-cyclodextrin (CD) and poly(L-lysine) dendron (PLLD) was synthesized, and then used for DOC and MMP-9 co-delivery. Different from commonly used amphiphilic copolymers micelles, the obtained CD derivative could be used directly for the combinatorial delivery of nucleic acid and hydrophobic DOC without a complicated micellization process. In vitro and in vivo ass...