Interleukin-1 gene (IL1) assigned to long arm of human chromosome 2.

作者：Andrew C. Webb, K L Collins, Philip E. Auron, R.L. Eddy, H. Nakai, Mary G. Byers, Linda L. Haley, W.M. Henry, Thomas B. Shows · 发表于：PubMed · 年份：1986 · 被引用次数：117 · 研究领域：Genetics and Neurodevelopmental Disorders、Neurogenetic and Muscular Disorders Research、RNA modifications and cancer

A complementary DNA (cDNA) probe for the predominant (pI 7) form of human monocyte-derived interleukin-1 (IL1) and a collection of 30 human-mouse somatic cell hybrids were used to assign the IL1 gene to human chromosome 2 by Southern blot analysis of hybrid cell DNA digested with the restriction endonuclease BglII. In situ hybridization to human metaphase chromosomes localized the IL1 gene to the long arm of chromosome 2 at position 2q13-2q21 between two fragile sites.