[Effect of flavonoids from hedysari radix on pulmonary functions of pulmonary fibrosis rat].

作者：Juan Li, Xingyao Lin, Jintian Li, Yi Zhang, Xueyan Li, Yongqi Liu, Ming Jing, Shaobo Sun, Yun Su, Guangwei Liu · 发表于：PubMed · 年份：2013 · 被引用次数：5 · 研究领域：Pharmacology、Medicine、Chemistry、Internal medicine、Biology、Botany

OBJECTIVE: To study the effect of flavonoids from Hedysari Radix on pulmonary functions of pulmonary fibrosis rat and its mechanism. METHODS: 72 Wistar rats were randomly divided into 6 groups: blank control group, model group, prednisone group, Hedysari Radix flavonoids low, medium and high dosage group. The rat model was established by propelling bleomycin into bronchial tree through endotracheal intubation with laryngoscope. The pulmonary fanctions were measured. RESULTS: Hedysari Radix flavonoids could normalize the pulmonary functions of rats with bleomycin-induced pulmonary fibrosis. CONCLUSION: Hedysari Radix flavonoids can inhibit the process of pulmonary fibrosis.