Loss of miR-1258 contributes to carcinogenesis and progression of liver cancer through targeting CDC28 protein kinase regulatory subunit 1B

作者：Minghua Hu, Mingwei Wang, Huihong Lu, Xiaoming Wang, Xiaoshan Fang, Jinguo Wang, Chenyang Ma, Xiaobing Chen, Hongping Xia · 发表于：Oncotarget · 年份：2016 · DOI：10.18632/oncotarget.9728 · 被引用次数：32 · 研究领域：MicroRNA in disease regulation、RNA modifications and cancer、RNA Research and Splicing

// Minghua Hu 1, * , Mingwei Wang 2, * , Huihong Lu 4, * , Xiaoming Wang 1 , Xiaoshan Fang 1 , Jinguo Wang 1 , Chenyang Ma 1 , Xiaobing Chen 3 , Hongping Xia 1 1 Department of Hepatobiliary Surgery, Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, 241001, China 2 Division of Cardiovascular Medicine, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, China 3 Department of Oncology, The Affiliated Cancer Hospital, Zhengzhou University, Zhengzhou, 450008, China 4 Department of Anesthesiology, East Hospital, Tongji University School of Medicine, Shanghai, 200120, China * These authors contributed equally to this work Correspondence to: Hongping Xia, email: xiahp82@gmail.com Xiaobing Chen, email: 2290773710@qq.com Keywords: miR-1258, liver cancer, recurrence, stemness, CKS1B Received: March 14, 2016      Accepted: May 05, 2016      Published: May 30, 2016 ABSTRACT Hepatocellular carcinoma (HCC) is the leading cause of cancer related death worldwide. The number of deaths is proportional to the global incidence, which highlights the aggressive tumor biology and lack of effective therapies. Dysregulation of microRNAs has been implicated in carcinogenesis and progression of liver cancer. Here, we identified that miR-1258 was significantly downregulated in HCC and associated with poor patients’ survival. Overexpression of miR-1258 significantly inhibits liver cancer cell growth, proliferation and...