Reduced CD146 expression promotes tumorigenesis and cancer stemness in colorectal cancer through activating Wnt/β-catenin signaling

作者：Dan Liu, Lei Du, Dong Chen, Zhongde Ye, Hongxia Duan, Tao Tu, Jing Feng, Yili Yang, Quan Chen, Xiyun Yan · 发表于：Oncotarget · 年份：2016 · DOI：10.18632/oncotarget.9930 · 被引用次数：50 · 研究领域：Cancer Cells and Metastasis、Wnt/β-catenin signaling in development and cancer、MicroRNA in disease regulation

// Dan Liu 1, 5 , Lei Du 2 , Dong Chen 3 , Zhongde Ye 1 , Hongxia Duan 1 , Tao Tu 1 , Jing Feng 1 , Yili Yang 4 , Quan Chen 2 , Xiyun Yan 1 1 Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China 2 State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China 3 Department of Pathology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China 4 Department of Colorectal Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China 5 College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China Correspondence to: Xiyun Yan, email: yanxy@ibp.ac.cn Keywords: stemness, CD146, tumorigenesis, Wnt/β-catenin, colorectal cancer Received: September 09, 2015      Accepted: April 18, 2016      Published: June 09, 2016 ABSTRACT Cancer stemness drives tumor progression and drug resistance, representing a challenge to cancer eradication. Compelling evidence indicates that cancer cells can reenter the stem cell state due to the reprogramming of self-renewal machinery. Here, we show that CD146 knockdown induces stem cell properties in colorectal cancer (CRC) cells through activating canonical Wnt signaling. shRNA-mediated CD146 knockdown in CRC cells facilitates tumor initiation in serial xenotransplantation e...