Frequency of a Deletion Polymorphism in the Gene for Angiotensin Converting Enzyme Is Increased in African-Americans With Hypertension

作者：Kenrik Duru, Stephen L. Farrow, Jiaming Wang, Warren E. Lockette, Theodore W. Kurtz · 发表于：American Journal of Hypertension · 年份：1994 · DOI：10.1093/ajh/7.8.759 · 被引用次数：138 · 研究领域：Nutrition, Genetics, and Disease、Renin-Angiotensin System Studies

In white populations, a deletion polymorphism in the gene for angiotensin converting enzyme (ACE) appears to be associated with increased risk for myocardial infarction but not for hypertension. In a population-association study in African-Americans, we compared the frequency of the ACE deletion polymorphism in subjects with hypertension versus those with normal blood pressure. The frequency of the ACE deletion allele was greater in African-Americans with hypertension than in those with normal blood pressure (P < 0.05). These findings raise the possibility that in some patient subgroups, sequence variation in or near the ACE gene may contribute to the risk for hypertension.