Efficient Palladium-Catalyzed C–H Fluorination of C(sp3)–H Bonds: Synthesis of β-Fluorinated Carboxylic Acids

作者：Qihua Zhu, Dezhong Ji, Tingting Liang, Xueyan Wang, Yungen Xu · 发表于：Organic Letters · 年份：2015 · DOI：10.1021/acs.orglett.5b01774 · 被引用次数：87 · 研究领域：Fluorine in Organic Chemistry、Catalytic C–H Functionalization Methods、Radical Photochemical Reactions

A novel and facile process for direct fluorination of unactivated C(sp3)-H bonds at the β position of carboxylic acids was accomplished by a palladium(II)-catalyzed C-H activation. The addition of Ag2O and pivalic acid was found to be crucial for the success of this transformation. This reaction provides a versatile strategy for the synthesis of β-fluorinated carboxylic acids.