Prenylated Polyhydroxy-p-terphenyls from Aspergillus taichungensis ZHN-7-07

作者：Shengxin Cai, Shiwei Sun, Huinan Zhou, Xianglan Kong, Tianjiao Zhu, Dehai Li, Qianqun Gu · 发表于：Journal of Natural Products · 年份：2011 · DOI：10.1021/np2000478 · 被引用次数：69 · 研究领域：Microbial Natural Products and Biosynthesis、Fungal Biology and Applications、Mycotoxins in Agriculture and Food

Six new prenylated polyhydroxy-p-terphenyl metabolites, named prenylterphenyllins A-C (1-3) and prenylcandidusins A-C (5-7), and one new polyhydroxy-p-terphenyl with a simple tricyclic C-18 skeleton, named 4''-dehydro-3-hydroxyterphenyllin (4), were obtained together with eight known analogues (8-15) from Aspergillus taichungensis ZHN-7-07, a root soil fungus isolated from the mangrove plant Acrostichum aureum. Their structures were determined by spectroscopic methods, and their cytotoxicity was evaluated using HL-60, A-549, and P-388 cell lines. Compounds 1 and 8 exhibited moderate activities against all three cell lines (IC50 1.53-10.90 μM), whereas compounds 4 and 6 displayed moderate activities only against the P-388 cell line (IC50 of 2.70 and 1.57 μM, respectively).