Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis

作者：Megan K. Ruhland, Andrew J. Loza, Aude-Hélène Capietto, Xianmin Luo, Brett L. Knolhoff, Kevin C. Flanagan, Brian A. Belt, Elise Alspach, K. Leahy, Jingqin Luo, András Schaffer, John R. Edwards, Gregory D. Longmore, Roberta Faccio, David G. DeNardo, Sheila A. Stewart · 发表于：Nature Communications · 年份：2016 · DOI：10.1038/ncomms11762 · 被引用次数：495 · 研究领域：Immune cells in cancer、Telomeres, Telomerase, and Senescence、Immunotherapy and Immune Responses

Age is a significant risk factor for the development of cancer. However, the mechanisms that drive age-related increases in cancer remain poorly understood. To determine if senescent stromal cells influence tumorigenesis, we develop a mouse model that mimics the aged skin microenvironment. Using this model, here we find that senescent stromal cells are sufficient to drive localized increases in suppressive myeloid cells that contributed to tumour promotion. Further, we find that the stromal-derived senescence-associated secretory phenotype factor interleukin-6 orchestrates both increases in suppressive myeloid cells and their ability to inhibit anti-tumour T-cell responses. Significantly, in aged, cancer-free individuals, we find similar increases in immune cells that also localize near senescent stromal cells. This work provides evidence that the accumulation of senescent stromal cells is sufficient to establish a tumour-permissive, chronic inflammatory microenvironment that can shelter incipient tumour cells, thus allowing them to proliferate and progress unabated by the immune system.