Adult Human and Mouse Ovaries Lack DDX4-Expressing Functional Oogonial Stem Cells

作者：Hua Zhang, Sarita Panula, Sophie Petropoulos, Daniel Edsgärd, Kiran Busayavalasa, Lian Liu, Xin Li, Sanjiv Risal, Yan Shen, Jingchen Shao, Meng Liu, Susann Li, Dongdong Zhang, Xiaoxi Zhang, Romana R. Gerner, Mona Sheikhi, Pauliina Damdimopoulou, Rickard Sandberg, Iyadh Douagi, Jan-Ακε Gustafsson, Lin Liu, Fredrik Lanner, Outi Hovatta, Kui Liu · 发表于：Obstetrical & Gynecological Survey · 年份：2016 · DOI：10.1097/01.ogx.0000475999.14943.7b · 被引用次数：40 · 研究领域：Genetics, Aging, and Longevity in Model Organisms、Reproductive Biology and Fertility、Pluripotent Stem Cells Research

Obstet Gynecol Surv 2016;71(1):29–30 The generally accepted viewpoint for more than 50 years has been that the number of oocytes is fixed in fetal or neonatal ovaries, and therefore, oocytes cannot renew themselves in postnatal or adult life. Over the past decade, however, the traditional viewpoint has been challenged by a number of investigators who have presented evidence that postnatal follicular renewal occurs in mammals, and that mitotically active oogonial stem cells (OSCs) exist in postnatal mouse ovaries.