Apparent Theophylline Half-Life Fluctuations During Treatment of Acute Left Ventricular Failure

作者：John W. Jenne, Thomas W. Chick, Bruce Alan Miller, Richard D. Strickland · 发表于：American Journal of Health-System Pharmacy · 年份：1977 · DOI：10.1093/ajhp/34.4.408 · 被引用次数：38 · 研究领域：Fungal Plant Pathogen Control、Analytical Methods in Pharmaceuticals、Heart Failure Treatment and Management

The administration of theophylline in a 63-year-old man with arteriosclerotic heart disease and chronic bronchitis is discussed to illustrate the pharmacokinetics of theophylline in an abnormal host state. The case demonstrates that clearly acute congestive heart failure and its treatment may dramatically affect the kinetics of theophylline elimination. Possible explanations for this phenomenon are presented, and the therapeutic implications are discussed.