Incidence and Mortality Risks of Cancer in Patients with Type 2 Diabetes: A Retrospective Study in Shanghai, China

作者：Yunjuan Gu, Xuhong Hou, Ying Zheng, Chunfang Wang, Lei Zhang, Jie Li, Zhezhou Huang, Ming Han, Yuqian Bao, Weijian Zhong, Weiping Jia, Shiwei Cui · 发表于：International Journal of Environmental Research and Public Health · 年份：2016 · DOI：10.3390/ijerph13060559 · 被引用次数：17 · 研究领域：Metabolism, Diabetes, and Cancer、Pancreatic and Hepatic Oncology Research、Cancer Risks and Factors

BACKGROUND: Evidence from epidemiologic investigation indicates that people with type 2 diabetes (T2DM) are at a significantly higher risk of many types of cancer and mortality. The aim of this study was to investigate the incidence and mortality risks of cancer in patients with T2DM compared with the general population in Shanghai, China. METHODS: Based on the Shanghai Diabetes Registry (SDR) database linking to the Shanghai Cancer Registry and Surveillance System (SCRSS), a total of 12,276 T2DM patients without cancer were defined and followed up from 1 December 2001 to 31 July 2011. Standardized incidence ratio (SIR) and standardized mortality ratio (SMR) with 95% confidence interval (CI) were calculated using the whole gender and age-matched general population of Shanghai as a reference during the same period. RESULTS: The overall cancer risk was found higher in both males and females T2DM patients, with the SIR of 3.14 (95% CI 2.73-3.56) and 4.29 (95% CI 3.64-4.94), respectively. The overall mortality risk of cancer also significantly increased with the SMR of 2.27 (95% CI 1.86-2.68) and 1.86 (95% CI 1.46-2.26), respectively. Pancreatic cancer was with the highest SIR and SMR in both genders. CONCLUSIONS: Compared with the general population, patients with T2DM were associated with higher incidence and mortality risks of cancer, especially pancreatic cancer.