Treatment Target in Schizophrenia: A Critical Review and a Clinical Suggestion

作者：Takefumi Suzuki, Hiroyuki Uchida, Koichiro Watanabe, Haruo Kashima · 发表于：Psychopharmacology Bulletin · 年份：2025 · DOI：10.64719/pb.4102 · 被引用次数：16 · 研究领域：Schizophrenia research and treatment、Mental Health and Psychiatry、Bipolar Disorder and Treatment

BACKGROUND: Patients with schizophrenia have many problems as well as symptoms, and various rating scales have been in use to address them. METHOD: The authors review past representative rating scales and some pivotal studies to focus on treatment target in schizophrenia. RESULTS: Traditionally, positive symptoms have been the main target of treatment. However, other crucial domains such as negative and cognitive symptoms, and subjective perspectives are drawing due attention because of their clinical relevance. Given many domains to be addressed, there have eventually been too many assessment scales to be selected and widely utilized in real-world clinical settings, and there has been still no concrete consensus on which scales to utilize in a given situation, which is currently decided at the discretion of the investigators. Measurement is frequently difficult even with the existing assessments, especially as what constitutes an acceptable clinical status is hard to define, considering highly hetero generous nature of the illness. Many rating scales are met with limitations especially in time and in pragmatic comprehensiveness, which often hinder their routine application in time-limited busy settings. Still, problems and functioning of patients are the reasonable target to evaluate for measurement-based treatment. CONCLUSIONS: The authors suggest assessment of problems resulting from symptoms together with objective functioning, which clinical psychiatrists are actually do...