The hnRNP family: insights into their role in health and disease

作者：Thomas Geuens, Delphine Bouhy, Vincent Timmerman · 发表于：Human Genetics · 年份：2016 · DOI：10.1007/s00439-016-1683-5 · 被引用次数：1183 · 研究领域：RNA Research and Splicing、Neurogenetic and Muscular Disorders Research、RNA modifications and cancer

Heterogeneous nuclear ribonucleoproteins (hnRNPs) represent a large family of RNA-binding proteins (RBPs) that contribute to multiple aspects of nucleic acid metabolism including alternative splicing, mRNA stabilization, and transcriptional and translational regulation. Many hnRNPs share general features, but differ in domain composition and functional properties. This review will discuss the current knowledge about the different hnRNP family members, focusing on their structural and functional divergence. Additionally, we will highlight their involvement in neurodegenerative diseases and cancer, and the potential to develop RNA-based therapies.