Phase I study with cell wall skeleton of Nocardia rubra.

作者：Yasuhisa Yamamura, Takeshi Ogura, Fumio Hirao, Kosei Yasumoto, K Sawamura, Satomi Hattori, Y. Hayata, Seiji Kishimoto, Kayo Yamada, H Niitani, T Masaoka · 发表于：PubMed · 年份：1981 · 被引用次数：6 · 研究领域：Actinomycetales infections and treatment、Infectious Diseases and Mycology、Mycobacterium research and diagnosis

Toxicity of the cell wall skeleton of Nocardia rubra (N-CWS) was evaluated in 60 patients with lung cancer, leukemia, and malignant melanoma who were given the agent intratumorally, intrapleurally, and intradermally in doses of 100-2000 micrograms. Fever was the most common toxic effect and was more frequent after intratumoral and intrapleural doses than after intradermal doses. The other predominant reaction was skin lesions such as erythema, induration, and abscess at the injection sites.