Non-Transgenic Mouse Models of Kidney Disease

作者：Michael Rabe, Franz Schaefer · 发表于：˜The œNephron journals/Nephron journals · 年份：2016 · DOI：10.1159/000445171 · 被引用次数：1926 · 研究领域：Renal and Vascular Pathologies、Renin-Angiotensin System Studies、Renal Diseases and Glomerulopathies

Animal models are essential tools to understand the mechanisms underlying the development and progression of renal disease and to study potential therapeutic approaches. Recently, interventional models suitable to induce acute and chronic kidney disease in the mouse have become a focus of interest due to the wide availability of genetically engineered mouse lines. These models differ by their damaging mechanism (cell toxicity, immune mechanisms, surgical renal mass reduction, ischemia, hypertension, ureter obstruction etc.), functional and histomorphological phenotype and disease evolution. The susceptibility to a damaging mechanism often depends on strain and gender. The C57BL/6 strain, the most commonly used genetic background of transgenic mice, appears to be relatively resistant against developing glomerulosclerosis, proteinuria and hypertension. This review serves to provide a comprehensive overview of interventional mouse models of acute and chronic kidney disease.