Relationship of lipoprotein lipase activity to triglyceride uptake in adipose tissue

作者：Arlene S. Garfinkel, Nome Baker, Michael C. Schotz · 发表于：Journal of Lipid Research · 年份：1967 · DOI：10.1016/s0022-2275(20)40148-8 · 被引用次数：114 · 研究领域：Diabetes, Cardiovascular Risks, and Lipoproteins、Adipose Tissue and Metabolism、Adipokines, Inflammation, and Metabolic Diseases

Fasted rats injected with actinomycin or fed glucose show increased lipoprotein lipase activity of epididymal adipose tissue. Data from the actinomycin-treated animals showed a direct correlation between the lipoprotein lipase activity and the uptake of lipoprotein triglyceride by the epididymal fat pad in vitro and in vivo. Data from the animals fed glucose confirmed these findings in vitro. These data strongly suggest that lipoprotein lipase plays a major role in triglyceride deposition in adipose tissue.