Genetic analyses of GII.17 norovirus strains in diarrheal disease outbreaks from December 2014 to March 2015 in Japan reveal a novel polymerase sequence and amino acid substitutions in the capsid region

作者：Yuki Matsushima, Mariko Ishikawa, Tomomi Shimizu, Ayako Komane, Shizuko Kasuo, M. Shinohara, Kinzo Nagasawa, Hirokazu Kimura, Akihide Ryo, N. Okabe, Kei Haga, Yen Hai Doan, Kazuhiko Katayama, Hideaki Shimizu · 发表于：Eurosurveillance · 年份：2015 · DOI：10.2807/1560-7917.es2015.20.26.21173 · 被引用次数：231 · 研究领域：Viral gastroenteritis research and epidemiology、Animal Virus Infections Studies、Bacteriophages and microbial interactions

A novel GII.P17-GII.17 variant norovirus emerged as a major cause of norovirus outbreaks from December 2014 to March 2015 in Japan. Named Hu/GII/JP/2014/GII.P17-GII.17, this variant has a newly identified GII.P17 type RNA-dependent RNA polymerase, while the capsid sequence displays amino acid substitutions around histo-blood group antigen (HBGA) binding sites. Several variants caused by mutations in the capsid region have previously been observed in the GII.4 genotype. Monitoring the GII.17 variant's geographical spread and evolution is important.