Variants in human papillomavirus receptor and associated genes are associated with type-specific HPV infection and lesion progression of the cervix

作者：Jian Zou, Zhu Cao, Jianyang Zhang, Tingting Chen, Shizhou Yang, Yongjie Huang, Die Hong, Yang Li, Xiaojing Chen, Xinyu Wang, Xiaodong Cheng, Weiguo Lü, Xing Xie · 发表于：Oncotarget · 年份：2016 · DOI：10.18632/oncotarget.9510 · 被引用次数：21 · 研究领域：Cervical Cancer and HPV Research、Reproductive tract infections research、Hepatitis B Virus Studies

// Jian Zou 1, 2, * , Zhu Cao 1, 2, * , Jianyang Zhang 1, 2, * , Tingting Chen 1, 2 , Shizhou Yang 1, 2 , Yongjie Huang 1, 2 , Die Hong 1 , Yang Li 1 , Xiaojing Chen 2 , Xinyu Wang 1 , Xiaodong Cheng 1 , Weiguo Lu 1, 2 , Xing Xie 1, 2 1 The Department of Gynecologic Oncology, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, China 2 Women’s Reproductive Health Laboratory of Zhejiang Province, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, China * These authors have contributed equally to this work Correspondence to: Xing Xie, email: xiex@zju.edu.cn Keywords: HPV receptor, SNP, type-specific HPV infection, cervical lesions Received: February 16, 2016      Accepted: April 26, 2016      Published: May 20, 2016 ABSTRACT Human papillomavirus (HPV) infects cervical epithelial cells through cellular membrane receptors, and then induces the initiation and progression of cervical cancer. Single nucleotide polymorphisms (SNPs) may impact the susceptibility and outcome of diseases, but it’s still unknown whether variant in HPV receptor and associated genes is associated with type-specific HPV infection and cervical lesion progression. We examined 96 SNPs in 8 genes which may participate in the HPV infection process in 875 samples with HPV negative or single HPV16, 18, 52, 58 positive from 3299 cervical exfoliated cell samples, by Illumina B...