Infrared Assessment of Bone Quality: A Review

作者：Eleftherios P. Paschalis, Richard Mendelsohn, Adele L. Boskey · 发表于：Clinical Orthopaedics and Related Research · 年份：2011 · DOI：10.1007/s11999-010-1751-4 · 被引用次数：220 · 研究领域：Bone health and osteoporosis research、Spectroscopy Techniques in Biomedical and Chemical Research、Bone Tissue Engineering Materials

BACKGROUND: Bone strength depends on both bone quantity and quality. The former is routinely estimated in clinical settings through bone mineral density measurements but not the latter. Bone quality encompasses the structural and material properties of bone. Although its importance is appreciated, its contribution in determining bone strength has been difficult to precisely quantify partly because it is multifactorial and requires investigation of all bone hierarchical levels. Fourier transform infrared spectroscopy provides one way to explore these levels. QUESTIONS/PURPOSES: The purposes of our review were to (1) provide a brief overview of Fourier transform infrared spectroscopy as a way to establish bone quality, (2) review the major bone material parameters determined from Fourier transform infrared spectroscopy, and (3) review the role of Fourier transform infrared microspectroscopic analysis in establishing bone quality. METHODS: We used the ISI Web of Knowledge database initially to identify articles containing the Boolean term "infrared" AND "bone." We then focused on articles on infrared spectroscopy in bone-related journals. RESULTS: Infrared spectroscopy provides information on bone material properties. Their microspectroscopic versions allow one to establish these properties as a function of anatomic location, mineralization extent, and bone metabolic activity. It provides answers pertaining to the contribution of mineral to matrix ratio, mineral maturity, minera...