Lineage infidelity of a human myelogenous leukemia cell line

作者：Antonio Pierangelo Palumbo, Jun Minowada, Jan Erikson, C M Croce, G Rovera · 发表于：Blood · 年份：1984 · DOI：10.1182/blood.v64.5.1059.1059 · 被引用次数：77 · 研究领域：Acute Myeloid Leukemia Research、Chronic Myeloid Leukemia Treatments、Chronic Lymphocytic Leukemia Research

We have analyzed the organization and expression of the immunoglobulin heavy and light chain gene in the human myeloblastic leukemic sublines, ML1, ML2, and ML3, and in the human myeloid leukemic cell lines, HL-60, U937, THP1, and K562. ML1, ML2, and ML3 cells, despite a predominant granulocytic phenotype, express a rearrangement of the immunoglobulin heavy chain gene that typically occurs during the early stages of the B cell differentiation pathway. No rearrangement was found in any of the other cell lines tested. These findings strongly support the notion that, at least in some cases, acute myeloid leukemia (AML) cells represent highly atypical cells with profoundly altered gene expression, rather than cells arrested at a well-defined stage of the myeloid lineage.