HEPARIN‐RELEASED BLOOD PLASMA LIPOPROTEIN LIPASE ACTIVITY IN PATIENTS WITH HYPERLIPOPROTEINEMIA

作者：Jonas Boberg · 发表于：Journal of Internal Medicine · 年份：1972 · DOI：10.1111/j.1365-2796.1972.tb00017.x · 被引用次数：54 · 研究领域：Lipid metabolism and disorders、Diabetes, Cardiovascular Risks, and Lipoproteins、Lipoproteins and Cardiovascular Health

Abstract Plasma lipoprotein lipase (LPL) activity appearance in the blood stream after different doses of i.v. injection of heparin has been studied. After 100 IU of heparin/kg b.wt. LPL activity was found to rise rapidly for about 5 min and then more slowly up to a maximum activity at 20 to 40 min. The possibility that the different appearance rates might reflect several enzyme pools not equally accessible to injected heparin has been discussed. Against this background plasma LPL activity was determined both at 5 and 40 min after i.v. injection of 100 IU of heparin/kg b.wt. in subjects with a wide range of plasma triglyceride (TG) concentrations. There was no relationship either in men or women between heparin‐released plasma LPL activities and age or weight/height index. In men with normal plasma TG values on the day of heparin injection the heparin‐released LPL activities in plasma were 49 ± 2 and 100 ± 4 μmoles glycerol released pre litre plasma and minute in the early and late samples respectively. The corresponding values of 40±3 and 72±6 for men with hypertriglyceridemia were significantly lower. In women with normal plasma TG values the LPL activities 5 and 40 min after heparin were 71±4 and 127 ± 7 μmol/1 and min respectively. These values were significantly higher than the corresponding values for normal men. The women with hypertriglyceridemia had plasma LPL activities 5 and 40 min after heparin of 45 ± 7 and 85 + 10 μmol/1 and min, which were significantly lower t...