L1CAM: Cell adhesion and more

作者：Timur R. Samatov, Daniel Wicklein, Alexander Tonevitsky · 发表于：Progress in Histochemistry and Cytochemistry · 年份：2016 · DOI：10.1016/j.proghi.2016.05.001 · 被引用次数：84 · 研究领域：Glycosylation and Glycoproteins Research、Caveolin-1 and cellular processes、Neuropeptides and Animal Physiology

L1CAM is a cell adhesion molecule of the immunoglobulin superfamily which was originally discovered as a major player in the development of the nervous system. L1CAM was demonstrated to have prognostic value in different cancers and to be a promising target for anti-cancer therapy. Here we overview the present data on L1CAM structure and function, regulation of its expression, role in cancer and therapeutic potential.