The roles on intraluminal oxygen and glucose in the protection of the rat intestinal mucosa from the effects of ischaemia.

作者：Robinson Jw, V MIRKOVITCH · 发表于：PubMed · 年份：1977 · 被引用次数：27 · 研究领域：Cardiac Ischemia and Reperfusion、Diet and metabolism studies、Nitric Oxide and Endothelin Effects

Rat ileal loops were subjected to 15 minutes ischaemia by clamping both mesenteric and collateral vessels, after which the functional capacity of their mucosae was assessed according to their ability to accumulate phenylalanine "in vitro". Groups of intestines were rinsed before being subjected to ischaemia. Independent and additive protective effects were observed when the rinsing buffer was oxygenated and/or when it contained glucose. Indeed, an oxygenated, glucose-containing buffer afforded full protection to the mucosa, whereas a nitrogenated, glucose-free buffer had no action.