The inhibition of succinoxidase by heavy metals and its reactivation with dithiols

作者：E. S. Guzmán Barrón, George Kalnitsky · 发表于：Biochemical Journal · 年份：1947 · DOI：10.1042/bj0410346 · 被引用次数：78 · 研究领域：Biotin and Related Studies、Metal complexes synthesis and properties、Electrochemical Analysis and Applications

stability of the 'tissue acceptor' and antidotemercaptides, and the relative ease of penetration of inhibitor and antidote to the active centres.The increased oxygen uptake of brain dispersions brought about by the presence of BAL has been observed before, and has been shown to be due to a true stimulation ofthe enzyme activity (Stocken et al. 1947).SUMMARY The ability of 2:3-dimercaptopropanol (British Anti- Lewisite or 'BAL') to detoxicate compounds of antimony, gold and mercury has been demonstrated, using the pyruvate oxidase system of pigeon brain as a test system.This work was carried out for the Ministry of Supply as part of a larger programme under the direction of Pirof.R. A.