Cost of management of severe pneumonia in young children: systematic analysis

作者：Shanshan Zhang, Peter M. Sammon, Isobel King, Ana Lúcia Andrade, Cristiana Maria Toscano, Sheila N Araujo, Anushua Sinha, Shabir Ahmed Madhi, Gulam Khandaker, Jiehui Kevin Yin, Robert Booy, Tanvir Mahmudul Huda, Qazi Sadeq-ur Rahman, Shams El Arifeen, Ángela Gentile, Norberto Giglio, Mejbah Uddin Bhuiyan, Katharine M Sturm-Ramirez, Bradford D. Gessner, Mardiati Nadjib, Phyllis Carosone‐Link, Eric A. F. Simões, Jason Child, Imran Ahmed, Zulfiqar Ahmed Bhutta, Sajid Bashir Soofi, Rumana Jesmin Khan, Harry J. Campbell, Harish Nair · 发表于：Journal of Global Health · 年份：2016 · DOI：10.7189/jogh.06.010408 · 被引用次数：125 · 研究领域：Pneumonia and Respiratory Infections、Global Maternal and Child Health、Respiratory viral infections research

BACKGROUND: Childhood pneumonia is a major cause of childhood illness and the second leading cause of child death globally. Understanding the costs associated with the management of childhood pneumonia is essential for resource allocation and priority setting for child health. METHODS: We conducted a systematic review to identify studies reporting data on the cost of management of pneumonia in children younger than 5 years old. We collected unpublished cost data on non-severe, severe and very severe pneumonia through collaboration with an international working group. We extracted data on cost per episode, duration of hospital stay and unit cost of interventions for the management of pneumonia. The mean (95% confidence interval, CI) and median (interquartile range, IQR) treatment costs were estimated and reported where appropriate. RESULTS: We identified 24 published studies eligible for inclusion and supplemented these with data from 10 unpublished studies. The 34 studies included in the cost analysis contained data on more than 95 000 children with pneumonia from both low- and-middle income countries (LMIC) and high-income countries (HIC) covering all 6 WHO regions. The total cost (per episode) for management of severe pneumonia was US$ 4.3 (95% CI 1.5-8.7), US$ 51.7 (95% CI 17.4-91.0) and US$ 242.7 (95% CI 153.6-341.4)-559.4 (95% CI 268.9-886.3) in community, out-patient facilities and different levels of hospital in-patient settings in LMIC. Direct medical cost for severe ...