Brief Communication: Therapy of Advanced Colorectal Cancer With a Combination of 5-Flourouracil, Methyl-l,3-cis(2-chlorethyl)-1-nitrosourea, and Vincristine2

作者：C G Moertel, Allan J. Schutt, R. G. Hahn, Richard J. Reitemeier · 发表于：JNCI Journal of the National Cancer Institute · 年份：1975 · DOI：10.1093/jnci/54.1.69 · 被引用次数：163 · 研究领域：Cancer therapeutics and mechanisms

In a randomized, controlled study of 80 patients with advanced colorectal carcinoma, the combination of 5-fluorouracil (5-FU), methyl-1, 3-cis(2-chlorethyl)-1-nitrosourea, and vincristine produced an overall degree to toxicity comparable to that of 5-FU used alone. At 10 weeks, a positive objective response rate of 43.5% was observed with the three-drug combination compared to 19.5% with 5-FU alone (P less than 0.5).